Astroglial N‐myc downstream‐regulated gene 2 protects the brain from cerebral edema induced by stroke
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منابع مشابه
Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats
Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...
متن کاملAttenuation of thrombin-induced brain edema by cerebral thrombin preconditioning.
BACKGROUND AND PURPOSE Edema formation after intracerebral hemorrhage has been linked to thrombin toxicity induced by the clot. However, thrombin at low concentrations actually protects neurons and astrocytes in culture from hypoglycemic and ischemic cell death. It is also known that a brief episode of brain ischemia increases neuronal tolerance to a subsequent severe ischemic episode. The obje...
متن کاملO12: The Heart and the Brain: Stroke Induced Heart Damage
Cardiac diseases are common post-stroke and are associated with increased morbidity and mortality. One possible mechanism of acute cardiac injury is the neurogenic myocardial damage, where the cerebral injury is disturbing the normal sympathetic and parasympathetic neuronal outflow to the heart leading to cardiac damage including myocardial infarctions. The exact mechanism is not completely und...
متن کاملcandesartan attenuates ischemic brain edema and protects the blood–brain barrier integrity from ischemia/reperfusion injury in rats
background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...
متن کاملBrain Edema After Ischaemic Stroke
OBJECTIVES To determine the incidence of brain edema after ischaemic stroke and its impact on the outcome of patients in the acute phase of ischaemic stroke. PATIENTS AND METHODS We retrospectively analyzed 114 patients. Ischaemic stroke and brain edema are verified by computed tomography. The severity of stroke was determined by National Institutes of Health Stroke Scale. Laboratory findings...
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ژورنال
عنوان ژورنال: Glia
سال: 2020
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.23888